Ivermectin – Old Drug, New Tricks?

Trifluridine/Tipiracil: Old Drug, New Tricks

The comparison of oral Ivermectin and topical Gamma Benzene Hexachloride 1% in treatment of Scabies

Background: Oral ivermectin is recently introduced for the treatment of scabies. Objective: The objective of this clinical trial was to compare the efficacy and safety of oral ivermectin and topical Gamma Benzene Hexachloride (GBH) 1% for the treatment of scabies. Patients and Methods: Fifty-eight cases were randomly assigned in the two treatment groups. In the ivermectin group, patients receiv...

Mass treatment with ivermectin: an underutilized public health strategy.

Ivermectin was a revolutionary drug in the 1980s, the forerunner of a new group of antiparasitic agents with activity against both parasitic nematodes and arthropods. Initially it was marketed for veterinary use by Merck & Co. Inc.; it was used largely for nematode control in cattle, horses, pigs and dogs and became the standard for control of the ectoparasitic disease, scabies. The injectable ...

Teaching an old dog new tricks: drug repositioning in small cell lung cancer.

Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.

Resistance: what is new and on the horizon, and a time to teach old dogs new tricks?

Understanding HIV drug resistance has played a key role in the success of antiretroviral therapy. This knowledge allowed for the prediction of resistance evolution when a specific drug or combinations of drugs were administered, informing strategies implemented for initial and subsequent drug regimens. Resistance testing of individual patients detects transmitted as well as acquired drug resist...